Significance of p53 protein and PCNA expressed in gastric epithelial dysplasia

Objective To study significance of p53 protein and PCNA expressed in gastric epithelial mid- dle and high grade dysplasia. Methods The expressions of p53 protein and PCNA in 79 middle and high grade dysplastic epithelia of gastric mucosa obtained by endoscope were detected by immunohistochemical method,and 5 years follow-up study was carried out. ResultsThe detection rate of gastric carcinoma in the dysplastic epithelia with p53 positive was much higher than those with p5...