Nm23 Gene Exproession and Its Clinical Significance in Human Malignant Trophoblastic Tumors

Objective To study nm23 gene expression and its clinical significance in human malignant trophoblastic tumors (HMTT). Methods The expression of nm23 gene was studied immunohistochemically using LSAB method in 91 HMTT. Results The positive rate of nm23 gene expression in invasive mole(100%) was much more high than one in choriocarcinoma(68.63%)(p<0.01).The expression of nm23 was basically negative in neoplastic syncytiotrophoblast(ST),was partially positive in intermediate trophoblast(IT) and cytotrophob...