Clinicopathological significance of expression of p21~(WAF1) gene in gastric carcinoma and precancerous lesion
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Graphical Abstract
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Abstract
Objective To study the relationship between expression of p21WAF1 gene and carcinpogenesis, invasion and metastasis. Methods Expression of p21WAF1 protein was respectively examined by streptavidin- peroxidase conjugated method (SP) in normal gastric mucosa, dysplastic gastric mucosa and gastric carci- noma. Results The expression of p2lWAFi in 100% (20/20) of normal gastric mucosa and 92%(37/40) of dysplastic gastric mucosa was markedly higher than that in 39%(43/108) of gastric carcinoma (P<0. 05). The ...
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