Clinical Study of Sequential Intravesical Instillations for the Prevention of Bladder Cancer Recurrence after Surgical Management

Objective 　To determine the effect of sequential int ravesical instillation to prevent superficial bladder cancer recurrence and seek ideal methods of int ravesical instillation. Methods 　Four-five patients (34 men, 11 women) with superficial bladder cancer, mean age of 56. 1 years ( range 31～80), were randomly divided into three groups. A group received a single int ravesical instillation of epirubicin as control, B group and C group received different sequential int ravesical instillation of hydroxycamptothecine ( HCPT) and mitomycin Cn (MMC) individually. Results 　The mean follow-up are 26. 36 months, 36. 73 months and 24. 31 months for A, B, C groups. The recur rates are 54. 5 % ( 6/ 11 ), 27. 7 % ( 5/ 18 ), 6. 25 %(1/ 16) individually. Conclusion 　The result s showed that sequential int ravesical with HCPT and MMC in reason maybe have better effect s than a single int ravesical instillation of epirubicin.