Expression of p16 protein and cyclinD_1 protein in transitional cell carcinoma(TCC) of urinary bladder and their implications

Objective To explore the expression of p16 protein and cyclinD1 protein in the TCC of urinary bladder and their relations to the clinical stages, pathological grades and prognosis. Methods S-P immu- nochemical method was used to detect p16 and cyclinD1 proteins expression in 59 cases with the TCC of uri- nary bladder. Results Positive rate of p16 was 42. 4%, with the progress of the tumor of grade and stage, the positive rate of p16 protein decreased. Positive rate of cy...