The mutation and down-expression of p16 gene in human lung cancer

Objective To detect pl6 gene mutation and expression in human non-small cell lung cancer (NSCLS), and to study the relationship between p16 expression and clinicpathologic features and progno- sis. Methods With S-P immunohistochenistry method, we investigated piG protein expression. Mutation in exon 2 of p16/MTSJ gene was screened by PCR-SSCP analyzing with non-isotope silve staining method. Results The positive rate of piG expression in NSCLC and lung benigh diseases was...