Hypermethylation of CPG island of p15 and p16 genes in multiple myeloma

Objective To illustrate the role of hypermethylation of p15 and p16 genes in the pathogenesis of multiple myeloma. Methods By using methylation-specific PCR (MSP) technique,the methylation status of p15 and p16 genes in MM were analysed. Results p15 and p16 gene are completely methylated . However both p15 and p16 genes are unmethylated in KM3 cells. Hypermethylation of CPG island was observed in 52. 38% for p15 and 57. 14% for p16 in our group of MM patients. There were ...