Clinical Study on the Relationship between the Expression of Heparanase (Hpa) and the in Invasion, Metastasis and Prognosis in Hepatocellular Carcinoma

Objective The main aim of this investigation were to explore the expression of heparanase mRNA and protein in hepatocellular carcinoma (HCC) and the relationship between the expression of Hpa and clinical pathological features of HCC. Methods Reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to detect expression of the heparanase mRNA and protein in normal hepatic tissues, liver cancer cell line, tumor tissues and adjacent tissues of hepatocellular carcinoma...