X-irradiation Induces hMSH2 Expression in Nasopharyngeal Carcinoma Cells
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Graphical Abstract
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Abstract
Objective To study the effect of X-irradiation on hMSH2 expression in nasopharyngeal carcinoma(NPC) CNE-1 cells, and explore mechanisms of DNA mismatch repair after irradiation. Methods Control and experimental cells were irradiated with 0Gy and 10Gy respectively,and hMSH2 expression was tested by RT-PCR, immunocytochemistry and Western blot. Results The expression of hMSH2 mRNA and protein in experimental cells were increased after irradiation, and were significantly higher than those in control cells(P<...
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