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子宫颈癌雌激素及孕激素受体分析[J]. 肿瘤防治研究, 1996, 23(5): 283-285.
引用本文: 子宫颈癌雌激素及孕激素受体分析[J]. 肿瘤防治研究, 1996, 23(5): 283-285.
The analysis of estrogen (ER) and progesterone (PR) in cervical carcinoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(5): 283-285.
Citation: The analysis of estrogen (ER) and progesterone (PR) in cervical carcinoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(5): 283-285.

子宫颈癌雌激素及孕激素受体分析

The analysis of estrogen (ER) and progesterone (PR) in cervical carcinoma

  • 摘要: 1993年10月至1994年2月收集我院42例经病理证实的宫颈癌患者的宫颈活检标本?鳞癌41例,其中低分化11例,中分化30例;腺癌1例?临床分期Ⅱb12例,Ⅲb28例,Ⅳ期2例?绝经前患者30例,绝经后12例?采用酶联雌二醇?孕酮亲和组化法在石蜡切片上进行宫颈癌组织雌激素受体(ER)?孕激素受体(PR)半定量检测?标记切片内典型阳性细胞≥10%为ER或PR阳性,≤10%为ER或PR阴性?ER阳性率为57.1%,PR阳性率为64.3%,中分化鳞癌较低分化鳞癌ER?PR阳性率高,但无显著性差异;宫颈癌不同临床分期ER?PR阳性率无显著性差异;绝经前后ER?PR阳性率亦无显著性差异?本方法简单易行,阳性细胞定位好,可以观察阳性细胞的分布及其与组织类型的关系等优点,有一定的临床实用价值?

     

    Abstract: Abstract From 1993, 10 to 1994, 2. 42 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplasmic estrogen (ER) and progesterone (PR)receptors by E2-HRP and Pg-HRP histochemicalmethods. The results of this study showed that a total of 57. 1% with ER positive and 64. 3% with PR positive were found. The positive rate of ER and PR were compared with histologic grade,clinical stage and menstrual status. ER and PR positive rate was higher in cervical carcinoma with diffusely pattern than that in non-diffusely pattern, but it is not differents in statistics, So do clinical stage and pre or post menopausal. This messure has a good advantage in clinical assay and was easy to watch the distribution of the positive cells and the ralation with the histologic type.

     

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