胃复安引起锥体外系症状的临床分析——附26例报导

EXTRAPYAMIDAL SYNDROMES CAUSED BY METOCLOPRAMIDE: ANALYSIS OF 26CASES

摘要: 本文分析2813例应用胃复安止吐的病例，出现锥体外系症状者26例，中毒出现率0.92%，其中痉挛性斜颈12例(46%)，帕金森震颤6例(23%)，伸舌假性球麻痹和强直性张口或牙关紧闭各4例(15.4%)，停药和及时应用安定，可很快中止上述症状。本文还对其中毒的和解毒的机制进行讨论。

Abstract: Metoclopramide was used as a antiemetic in 2813 Patients. Extrapyramidal syndromes were noted in 26 cases and the incidence rate was0.29％. Thosesyndromes included spasmodic torticollis.12(46％) cases; parkinsons tremor, 6 (23％); tongue extension-a kind of the pseudobulbar paralysis, 4(15.4％); tonoclonic mouth-open or gnathospasmus, 4 (15.4％). All above-mentioned adverse reactions discontinued soon after withdrawal and treatment with valium. The mechanisms of intoxication and detoxication are discussed in this paper.