LAK细胞对大鼠乳腺癌实验性肺转移的抑制

INHIBITORY EFFCT OF LAK CELLS ON EXPERIMENTAL PULMONARY METASTASIS OF MAMMARY CARCINOMA (SST一2)IN SHR RATS

摘要: 被动输入淋巴细胞作为一种肿瘤免疫疗法曾盛行于七十年代,但由于效果不确实而未能推广应用,甚至连T细胞在免疫监视上的作用也被怀疑和否认。1982年NCI的Rosenberg等首次发现在白细胞介素Ⅱ存在下培养的淋巴细胞具有杀伤肿瘤细胞的作用,命名为淋巴因子活化性杀伤细胞。

Abstract: Lymphokme=activated killer cells (LAK) were induced from normal splenocytes with IL-2 .Passive administration of LAK cells inhibied the formation of ezperime- atal pulmonary metast asis of‘mammary carcinoma (SST-2)in SHR rats and the survival times of the tumor-bearing animals were prolonged, According to the result of in vitro 51Cr-release, it was clear that LAK cells could kill SST--2 ce11s,A more effective result was obtained when a combination of LAK cells and II，一2 was used.