中枢神经系统肿瘤的雌孕激素受体

ESTROGEN AND PROGESTERONE RECEPTORS IN CENTRAL NERVOUS SYSTEM TUMORS

摘要: 本文报告了42例中枢神经系统肿瘤的ER、PR状况。其中脑膜瘤10例,胶质瘤15例,神经纤维瘤8例,其他肿瘤9例。42例中,ER阳性者仅3例,占7.1%。PR阳性率:脑膜瘤组为60.0%,胶质瘤组为13.3%,神经纤维瘤组为37.5%,其他肿瘤组为11.1%。脑膜瘤PR含量明显高于胶质瘤、神经纤维瘤以及其他肿瘤。在脑膜瘤组,PR含量明显高于ER含量,提示脑膜瘤可能是孕激素的靶组织。神经纤维瘤组PR阳性率仅次于脑膜瘤,其PR含量也高于ER含量,与脑膜瘤类似。

Abstract: Forty-two neoplasms of central nervous system (10 meningiomas, 15 gliomas, 8 nearofibromas and others 9) were evaluated by progeiterone and estrogen receptors, The incidence of estrogen receptor (ER) in the series was 7.1% (3142) white the positive rate of progesterone receptor (PR)was 60.0% in meningioma, 13.3% in gliomas, 37.5% in neurofibromas and 11.1% in other tamers respectively The incidence of PR in neurofibromas was only Lower than that of meningiomas and meningioma like tumos, the value of PR was also higher than ER.