应用顺氯氨铂、鬼臼乙叉甙和平阳霉素联合治疗食道癌

CISPLATIN ETOPOSIDE AND PINGYANGMYCIN COMDINATION THERAPY FOR ESOPHAGEAL CARCINOMA

摘要: 本文报告了应用顺氯氦铵(DDP),鬼臼乙叉甙(VP—16)和平阳霉素.(PYm)联合治疗33例中晚期食道癌病人。完全缓解(CR)2例,部分缓解(PR)13审,微效(MR)11例,缓解率(CR⁺PR)45.4%,总有效率(CR⁺PR⁺MR)78.8%。本方案非随机分组分为大剂量DDP组:大剂量DDP组的缓解率(40.9%)低于小剂量DDP组的缓解率(54.5%),而总有效率大剂量DDP组(81.8%)高于小剂量DDP组(72.7%)。中位缓解期7个月。主要毒性反应为消化道反应、骨髓抑制、脱发及冷热反应。

Abstract: The article reported thirty—three cases of esophagus epidermoid carcinoma at the middle and advanced stages were treated by cisplatin (DDP), Etoposide (PV-16) and pingyangmycin (PYM). The results showed, two patieets achieved complete remission (CR), thirteen patients had partial remission(PR), Eleven patiects had minor remission (MR). was 45.4% and total response rates (CR+PR+MR) was 78.8%. Remission rate of high-dose DDP group (40.9%) was lower than that of low-dose DDP group (54.5%), while total responserates of high-dose DDP group (81.8%) was higher than that of low-dose DDP group (72.7%). The median remiss ion duration of all patienjs was seven months. main sideeffectsandtoxicity were nausea, vom ting, anorexia bone marrow depression, alopecia, chill and fever.