Abstract: The level of the serum high-density lipoprotein cholesterol (HDL-C) were detected in the hepatic cancer patients,the causes of its alteration were discussed too.The author suggested, it was very important, when the level of lipid in the bloodis not high, but the level of the concentration of the HDL-C and the ratio valueof the total cholesterol were altered, these may be the markers that reflected theliver parenchyma was damage or the distubance of the lipid metabolism was repair-ed.