顺氯氨铂、丝裂霉素和平阳霉素联合治疗食管癌41例结果

THE RESULTS OF 41 CASES ESOPHAGEAL CARCINOMA WITH COMBINATION CHEMOTHERAPY OF CISPLATIN, MITOMYCIN, AND PINGYANGMYCIN

摘要: 1986年7月～1987年12月采用顺氯氨铂、丝裂霉素、平阳霉素联合化疗治疗食管癌41例。完全缓解6例（14.6%），部分缓解17例（41.5%），微效9例（21.9%），稳定4例（9.8%），无效5例（12.2%）。完全缓解和部分缓解率（CR+PR）56.1%，总有效率（CR+PR+MR）78%，中位生存期7个月（2—32个月）。毒副反应有食欲减退，恶心、呕吐、脱发、发热、骨髓抑制。

Abstract: From July 1988 to December 1987, 1st Affitiated Hospital of Henan Medical University, forty-one patients with esophageal carcinoma were treated by combination chemotherapy of cisplatin，mitomycin，and pingyangmycin. The treatment results showed that 8 cases (14,6%)of""complete remission, 9 cases (21.9%) of minimal response, 4 cases (9.8%) of stable and 5 cases (12.2%) of progression. The complete and partial remission rate (CR+PR) was 56.1% and the total response rate (CR+PR+MR) 78%.The median survival was 7 months (range 2-32 months).The toxicities seen were anorexia，nausea，vomiting, alopecia, hyperpyraxia, and mid myelodelodepressiof.