Abstract: In the present study, GSTs levels in serum of different groups of people in Qidong City, a high risk area of liver cancer, were determined by means of biotin-avidin enzyme-linked, immunoassay (BA-ELISA).The results showed that the GSTs level of normal subjects in Qidong city (0,66土0.54ng/ml) was higher than that in Beijing (0.36土0.27ng/mI) Members of high cancer families, HBVsAg carriers and patients having a low-level fluctuating pattern of serum AFp are the population with high risk of Iiver cancer. The GSTs levels of 3 groups were 1.25士1.46, 1.43士1.44, and2.81士1.78ng/ml, respectively. It was significantly higher than in the normal . The higher GSTs level in the patients having a low-level fluctuating pattern of serum. AFP, may be nelatine to lecancenous hepatic lesions GSTs level in 57 liver cancer patients were 3.08土3.35ng/ml.This is a simple and rapid assay and coued be prediction of liver a useful aid the detection of liver dammage and in the high risk area of liver cancer, especially in the high risk area of liver cancer.