枢复宁防止肿瘤化疗所致呕吐的疗效观察

A Clinical Observation of Ondansetron for the Prevention of Emesis Induced by Tumor Chemotherapy

摘要: 本文报道用枢复宁防止肿瘤化疗所致呕吐，共计30例，其中12例在使用枢复宁前曾用灭吐灵（作为自身对照）.结果发现枢复宁组防止化疗呕吐的完全控制率、有效率均显着高于灭吐灵组（分别是63.3%16.7%、96.7%比58.3%,P<0.00）.且其副作用少而轻微。因此，枢复宁是-种安全而有效的止吐剂。

Abstract: In this research we evaluated the antiemetic efficacy of ondansetron and metoclopramide. 30 patients received ondansetron and 12 of these had been used metoclopramide before they were giv-en ondansetron. Patients receiving ondansetron had a higher rate of complete control of emesis than these used metoclopramide (63.30ovs. 16.7%，P<0.001). The response rate is higher as well (96" 7%vs. 58.3%，P<0. 001).Side effects of ondansetron were mild We conclude that on-dansetron has a highly antiemetic efficacy and is significantly superior to meto.l opramide for cotrolling emesis associated with tumor chemotherapy.