腺泡状软组织肉瘤临床病理及其组织发生的研究

Clinicopathological and Histogenic Study of Alreolar Soft Part Sarcoma

摘要: 报告31例腺泡状软组织肉瘤。此瘤最常发生于年轻人下肢，5年生存率为54.5%。28例作免疫组化，23例肌红蛋白阳性（82.1%），18例结蛋白阳性（64.3%），3例S-100蛋白阳性（10.7%）；而神经原特异性烯醇化酶、神经微丝、溶菌酶、α1-抗胰蛋白酶、第Ⅷ因子相关抗原、角蛋白、上皮膜抗原、波形蛋白均为阴性。2例作电镜观察，瘤细胞浆内可见特殊的菱形结晶。作者认为腺泡状软组织肉瘤与肌细胞性肿瘤的常见类型之间可能存在着内在联系。

Abstract: Thirty-one cases of alveolar soft part sarcoma (ASPS) were presented. The tumor affected mostly young, lower extremeties. The 5-year-survival-rate was 54.5%, Twenty-eight cases of ASPS were studied with 11 of immunohistochemical antiserum. Myoglobin-positive tumor cells were found in 23 cases (82.1%), desminpositive in 18 cases (64.3%) and S-100 proteinpositive tumor cells in 3 cases (10.7%) 3 the others were all negative. Electron Microscopically, the special rhombus crystalls were found in the cytoplasm of tumor cells of 2 cases.It is likely that ASPS has some relationship to the usual types of muscle cell tumors.