卵巢肿瘤雌孕激素受体、雌二醇、孕酮测定及其临床意义

Estrogen and progesterone receptors, serum estradiol and progesterone levels and clinical signifiance in ovarian tumors

摘要: 本文测定了50例卵巢肿瘤患者手术前后血浆雌二醇(E_2)和孕酮(P)水平.并用葡聚糖─活性碳吸附法(DCC)测定了50例卵巢肿瘤和6例正常卵巢组织胞浆雌(ERc)、孕(PRc)激素受体和胞核雌(ERn)、孕(PRn)激素受体.结果表明卵巢恶性肿瘤具有高的ERc、PRc和低的ERn、PRn、E_2和P.提示对卵巢肿瘤患者常规进行E_2、P测定,可作为鉴别卵巢恶性肿瘤的参考.对受体含量高的卵巢恶性肿瘤,有用内分泌治疗的可能和推测较好预后.

Abstract: Fifty patients with ovedan tumor were analyzed for preoperative and postoperative serum estradiol(E2) and progesterone (P) contents. Cytosol and nuclear estrogen (ERc, ERn) and progesterone (PRc, PRn) receptors were measured with the Dextran-coated Charcoal method in 50 ovarian tumors and 6 normal ovarian specimens. The results indicated that the contents of ERc and PRc were higher and contents of ERn, PRn, E2, P were lower in malignant ovarian tumor than normal ovary and benign ovarian tumor. This suggested that E2 and P measurement of the patients with ovarisn tumor could aid in the selection of malignant ovarian tumor. Malignant ovarian tumor with hign concentration of ER and PR have the posibility of endocrine therapy and a better prognosis.