恩丹西酮（Ondansetron）预防由顺铂引起恶心呕吐Ⅱ期临床研究报告
Ondansetron in the Prophylaxis of Cisplatin-Induced Nausea and Vomiting Phase Ⅱ clinical study report
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摘要: 本文报告43例接受顺铂化疗肿瘤患者,使用国产恩丹西酮与胃复安随机自身对照止吐研究,结果表明在化疗的第1~3天恩丹西酮组的进食情况及恶心呕吐程度均好于胃复安组、在控制呕吐方面第1、2天恩丹西酮组亦明显的优于胃复安组,CR+PR分别为81.4%、58.1%和27.9%、32.6%.结果与进口柩复宁疗效相同,能有效地预防顺铂所致的胃肠道反应,尤其在控制顺铂所致的急性呕吐方面,疗效满意,可望取代柩复宁.Abstract: Abstract Fourty-three cases with solid tumors were treated with cisplatin chemotherapy.we designed a regimen of use of Ondansetron (made,in chiaa) and metoclopramide in the prophylaxis of cisplatin induced mausea and vomiting. A total of 43 cases were rolled in the cross-over study.The anti-nausea and vomiting effect of Ondanseton was better than Metoclopramide.In the prophlaxis of vomitding CR+PR of the regimen of Ondansetron was 81.4% and 58.1% on day 1 and day 2, respectively. The regimen of Metoclopramide was 27.9% and 32. 6%, respectively. The results indicate that Ondansetron (made in china) is as good as Zofran in controling cisplatin-induced emesis,especially in acute emesis.It can replace Zofran.
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