CHOP方案治疗中、高度恶性非何杰金淋巴瘤的临床观察

Clinical observation of CHOP treatment in intermediate or high grade non-hodgkin's lymphoma (NHL)

摘要: 本文报告CHOP方案治疗30例中、高度非何杰金林巴瘤(NHI.)的临床观察.全组病例均经病理学证实.按成都NHL工作分类.化疗均达两周以上，43. 3%用药六周以上.治疗结果:全组完全缓解(CR)率63.300，总缓解率80%.27例初治病例的CR率70. 3%.复治3例，部分缓解(PR)率66. 7%.本组1, 3年生存率分别为66.7%、 40%.主要毒副反应为消化道反应，白细胞降低、脱发，少部分病例有心电图改变及肝功能损害.无致死性毒副反应发生.

Abstract: The result of 30 cases of intermediate or high grade NHL treated by CHOP regimen was re-ported. All cases were proved histologically. Result showed that for the whole group total response rate was 80%, and CR rate was 63. 3%.For 27 previously untreated cases CR rate was 70. 3%, for 3 previously treated cases PR rate was 66.7%.The survival rates at one, three years were 66.7% and 40%, respectively. Themain adverse reactions include leukopenia and alopecia. Some pa-bents showed EKG changes and hepatotoxicity.