胃癌中神经内分泌细胞的临床病理学意义

胃癌中神经内分泌细胞的临床病理学意义

The clinicopathological significance of neuroendocrine cells in gastric carcinoma

摘要

摘要: 本文应用铬粒素A（CgA）、胃泌素（GAS）、生长抑素（SS）及5-羟色胺（5-HT）对120例普通型胃癌用免疫组化SP法标记其神经内分泌细胞。结果表明：四种激素抗体检测，以CgA最敏感、阳性率最高为31.7%;高分化腺癌CgA阳性率显着高于低分化和未分化癌（P<0.05）,但高分化腺癌CgA阳性病例以（+）为主，未分化癌以（++）为主；而SS.5HT的阳性率，高、低分化腺癌均高于未分化癌（P>0.05）.CgA及5-HT阳性病例淋巴结转移率高于阴性病例（P<0.05）,CgA（++）病例术后生存期明显短于CgA（+）及CgA（-）者（P<0.05）,GAS、5-HT及SS阳性与阴性病例术后生存期无显着差异。

Abstract: One hundred and twenty cases of gastric carcinoma were examined with immunohistochemical SP method for chromogranin A (CgA),gastrin (GAS),somatostain (SS) and serotonin(5-HT)follows:Among four antibodies,CgA was most specific,31.7%gastric carcinoma had CgA-positive cells;the positive rate of CgA in the well differentiated carcinomas was higher than that of the poorly differentiated ones and undifferentiated carcinomas (P<0.05),CgA-positive undifferentiated carcinomas had more NE cells(++);but among different histological type,the positive rate of HT and SS in undifferentiated carcinomas was lower (P>0.05).CgA and HT positive cases had higher lymph node metastasis rate than the negative ones (P<0.05).The cases with CgA-positive cells(++)exhibited shorter survival time than those with few CgA-positive cells(+)and without CgA-positive cells

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