宫颈癌细胞产生的TDSF对IL－2的免疫抑制作用

Effect of Immunosuppressive Factor Produced By Cervical Cancer Cell On IL-2 Responsiveness

摘要: 人宫颈癌细胞产的免疫抑制因子（TDSF）作用于人外周血单个核细胞（PBMC）6小时，即可抑制IL-2产生，与对照组相比P<0.01.当TDSF存在时，经激活的PBMC效应细胞对外源性IL-2反应显着减弱，表明TDSF能抑制IL-2的作用。PHA-P刺激PBMC增殖，但TDSF使其增殖抑制。表明TDSF能抑制IL-2产生及其作用。抗癌药对TDSF的分泌有部分阻抑作用。

Abstract: Cervical cancer cell lines produced a tumor-derived immunosuppressive factor (TDSF ),which inhibited the production of IL-2 after 6h incubation with PBMC,the response of PBMC treated with PHA-p to exogeneous IL-2 was significantly decreased in the presence of TDSF,suggesting that could inhibit the res poinsiveness of IL-2.The effect of PBMC after being stimulated with PHA-p was significantly suppressed by TDSF in does-dependent manner.These finding suggest that the inhibitory action of TDSF on T cell activation and proliferation mediated with IL-2.The synthesis or secretion of TDSF in cervical were partially inhibited by anticancer drubs.