Abstract: The relation between metaplasia and histogenesis of gallbladder carcinoma wasstudied by means of histochemical and immunonhistochemical in 134 cases of benignand malignant lesions of human gallbladder. Mataplasia was demonstrated in alldysplasias and most of the metaplasia were intestinal-type metaplasia. The metaplasia of hording areas of the carcinoma was same with dysplasia. Metaplasia represented in 65. 1% gallbladder carcinoma. The positive rate of metaplasia was lowerin poor-differential carcinomas (P0. 01 ). The study suggested that intestinal-typemetaplasias of gallbladder epithelium was significantly related to development ofgallbladder carcinoma.