Abstract: Two siblings were suffered from Fanconi's anemia in their first decade.Their characteristic associated abnormalities include peripheral pancytopenia,hyperpigmentation,deformity of the thumbs and genital hypoplasia .One's disease transformed into leukemia in his 13 yrs old and the other's hemogram became very well by yrs treatment with traditional and western medicine.No previous report has been discoved of the association of Fanconi's anemia transforming leukemia in China .It indicated that the pathogenism of this family of Fanconi's anemia was differant from idiopathic aplastic anemia.