左旋咪唑对甲基戊基亚硝胺致大鼠食管癌作用的影响

Effects of levamisole on N-methyl-N-amylnitrosamine (MANA)induced esonhageal carcinogesis in rats

摘要: 本文旨在研究左旋咪唑对亚硝胺类致食管癌作用的影响。Wistar大鼠82只，以甲基戊基亚硝胺诱发食管癌前病变，分别预防性给于左旋咪唑、太洛龙。经105天后，检测食管癌前病变发生率，用高效液相色谱法测定血清MANA含量。结果显示左旋咪唑和太洛龙均有降低食管癌前病变发生率及血清MANA作用，但左旋咪唑使大鼠体重增长正常，而太洛龙则使其变慢，提示二者具有相似地预防亚硝胺类致食管癌作用，并且左旋咪唑优于太洛龙。

Abstract: The purpose of the paper is to study the effects of levamisole (Lev)on nitrosamines-induced esophageal carcinogenesis.The test carried out in 82 Wistar rats,precancerous lesions of the esophagus were induced by MANA 5mg.kg^-1sc.Lev lOmg kg^-1and tilorone (Til)15mg kg^-1were administraed P.O.on the 5 days before MANA given.After 105 days of experiment,the incidence of precancerous lesions of the esophagus was determined and quantity of MANA in serum was tested by high performance liquid chromatography in rats.The results showed that lev had a significant decreases of the incidence of precancerous lesions of the esophagus and quantity of MANA in serum of rats similar to Til,but weight of rats was increased with normality by Lav and slowly by Til.It suggested that Lev and Til have similar preventive action to nitrosamines induced esophageal carcinogenesis,and Lev better than Til.