前列腺特异性抗原检测及临床应用

Assay and Used of Prostate Spectisc Antigen

摘要: 本文应用ELISA法定量测定血清前列腺特异性抗原（PSA）并对检测中的影响因素进行探讨，结果表明：血清放置的时间、温度及标本采集时间、药盒厂家对PSA检测结果有影响。同时也对PSA用于前列腺癌的诊断，疗效监控及病理分型等问题进行探讨。以PSA＞5ng/ml作为前列腺癌的诊断其阳性符合率为81%，特异性为94%。PSA作为前列腺癌的诊断及疗效监控是一个重要指标，而作为前列腺癌的病理分型应注意病例差异。

Abstract: In this paper, the quantitative determine of Prostate Specific Antigen (PSA) with ELISA and to effect factor in determination was studied. The results showed that determination values of PSA there were effect with store time, temperature and collect of sample and kits. Positive rate 81%, Specificity rate 94% for diagnoss prostate carcimoma when PSA>5ng/ml. It was important tumor marker that diag-nosis and treat control of prostatic carcinoma, but we should attention to differen-tial case when used in pathological grading of prostatic carcinoma.