Abstract: In order to assess the prognostic value of blood vessel and lymphatic vessel invasion(BVI and LVI) in stage Ⅰ、Ⅱ resected nonsmall cell lung cancer.76 resected patientsfrom stage Ⅰ and Ⅱ NSCLC were followed.BVI and LVI were evaluated by light microscope in hematoxylin stain slides.Association among variables were tested by the Pearson chi-square test.Sue vival were analyzed by kaplan-Meier product-limit methodand the multivariable Cox model.The pattens' mean age was 56±8.2 years.Medianfollow-up was 5l months.Overall 3-year survival was 68% and overall 5-year sruvivalwas 64%.BVlwas present in 28% of NSCLC cases and LVI in 0.70%.BVI(＋)/or LVI(＋) was present in 34% of NSCLC.In univariate analysis, BVI ut not LVI was associated with poor survival (x²= 8.66, p=0.003).Cox regression multivariate analysisshowed vessel invasion(p=0.003) and lymph node status (p=0.01) were independentpredictors for poor overall survival.Our study suggested that vessel invasion was important pathological factor in evaluating prognosis of stage Ⅰand Ⅱ NSCLC.