碱性成纤维细胞生长因子在膀胱移行细胞癌中表达及其意义
Expression of bFGF in transitional cell carcinoma of the bladder
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摘要: 应用免疫组织化学技术,观察并探讨膀胱移行细胞癌中bFGF表达及其对肿瘤微血管形成能力及肿瘤细胞增殖能力的影响。结果显示:阳性反应物位于肿瘤细胞及逼尿肌细胞胞浆中,浸润型膀胱癌bFGF除肿瘤细胞合成外还来自对逼尿肌的破坏。表达阳性率为26.67％,其表达与临床分期、分级有明显关系(P<0.05)。并且表达组肿瘤微血管密度及增殖细胞指数均高于未表达组(P<0.05),提示bFGF在膀胱移行细胞癌中有促进微血管形成及肿瘤细胞增殖的作用。阳性组复发率及死亡率均高于阴性组则提示bFGF对肿瘤发展有重要作用。Abstract: In order to further study of the role of bFGF on angiogenesis and tumor cell proliferation in transitional cell carcinoma of the bladder, the expression of bFGF was assayedin 30 cases usingImmunohistochemical techineque. Results showed: 8 cases (26.67%) were positivefor bFGF staining, the rate of positive staining was in correlation with the stage and thegrade of tumors.The intratumor microvessel density and the proliferation cell lable inthe tissues with positive bFGF staining were significantly higher than those with negitive staining.Our results suggested that bFGF can improve angiogenesis and proliferation of tumor cell in transitional cell carcinoma of the bladder.
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