肝癌高发区高危人群的茶叶干预研究

An Intervention Trial with Tea on High Risk Population of Primary Liver Cancer in Qidong

摘要: 本研究采用具有严格对照设计的实验流行病学研究方法，在启东肝癌高发区对茶叶提取物在高危人群（甲胎蛋白低浓度阳性者）中是否具有预防或延缓肝癌发生的作用进行了较为客观的评价。结果显示，在10个月的观察期间干预组肝癌的发病率为15％（12/80），安慰剂对照组为14.1％（11/78），两组发病率无显著差异。干预前后各项生化指标如AFP、ALT、AKP、γ-GT以及乙型肝炎标志物的改变在干预组和对照组间均无统计学显著差异。本研究结果表明在这一特定的肝癌高危人群中给予茶叶提取物似无预防或延缓肝癌发生的作用。

Abstract: An intervention trial was conducted in order to elucidate the preventive effect of teaon the occurrence of primary liver cancer(PLC) in high risk population in Qidong county.The results showed that, in the 10 monthes observation period, the incidence rate of PLCwas 15 percent (12/80) in intervation group, and 14.1 percent (11/78) in placebo controlgroup. No significant difference was found between the two groups. After intervention,the changes of some biochemical markers such as AFP, ALT, AKP, Υ-GT and hepatitis Bvirus marders had no statistical difference between tea intervention group and controlgroup. The study suggested that tea had no preventive effect on the development of PLCin selected special high risk population.