Abstract: Based upon one case with merker cell carcinoma as verified by operation,light and elec tronmicroscope, immunohistochemistry. The diagnosis, the therapeutic method, pathagenicalfeature and prognosis and molecular biology are disscussed. The literatures are reviewed.Merkel cell carcinoma is a malignant tumor arising from the merkel cell of superficial skin, itbelong to the neuroendocrine tumor. It is rare in the Clinical practice. The head and neck are the most comman site for this carcinoma . It has an obvious tendency of recurrence and metastasis. The diagnosis is made on pathology. It resembles the lymphoma. CT examination should be done at early stage. It is advocated that the tumor should be excised adequately, corresponding lymph node dissection and following radiotherapy should be peroformed.The effect of chemotherapy can not be Proved. The poor prognostic factors are localrecurrence and extensive metastasis. The development of Merkel cell carcinoma is related to Bcl-2 gene and FHIT gene, but us to P⁵³