血清神经原特异性烯醇酶和胃泌素用于肺癌的临床价值

血清神经原特异性烯醇酶和胃泌素用于肺癌的临床价值

Clinical Value of Measurement of Serum Neuron Specific Enolase and Gastrin for Lung Cancer

摘要

摘要: 目的探讨血清神经原特异性烯醇酶（NSE）和胃泌素用于肺癌的临床价值。方法采用ABC-ELISA 和放免法检测30 例正常对照、25 例良性肺疾病、55 例非小细胞肺癌（NSCLC）和15 例小细胞肺癌（SCLC）血清NSE和胃泌素浓度。结果血清NSE和胃泌素浓度在4 组间有显着性差异（ P< 0-001）.NSE 诊断SCLC 的敏感性、特异性和准确性是80 、88 和86 % ;胃泌素诊断NSCLC分别是69 、65 和60 % 治疗后，SCLC 组血清NSE 和胃泌素均显着下降（ P< 0-001）, 而NSCLC组仅有胃泌素降低（ P< 0-001）。结论 NSE 主要用于SCLC 的辅助诊断、术前组织学分型及疗效监测，而胃泌素用于NSCLC。

Abstract: Objective To study the clinical value of measurement of serum neuron specific enolase (NSE) and gastrin for lung cancer. Methods serum NSE and gastrin were measured with ABC ELISA and Radioimmunoassay in 30 healthy subjects(C),25 patients with benign pulmonary diseases (BPD),55 patients with non small cell lung cancer (NSCLC) and 15 patients with small cell lung cancer (SCLC).Reaults The serum concentrations of NSE and gastrin had significant difference in the four groups ( P 0 001).The sensitivity,specificity and accuracy of NSE for SCLC were 80,88 and 86%,gastrin for NSCLC were 69,65 and 60%,respectively.After the patients with lung cancer were treated,serum levels of NSE and gastrin were significantly decreased in SCLC ( P 0 001),but levels of gastrin were decreased in NSCLC only ( P 0 001). Conclusion NSE should be used in adjuvant diagnosing,preoperative histological typing and therapy monitoring for SCLC,and gastrin for NSCLC.

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