肝细胞癌患者庚型肝炎病毒的感染

Hepatitis G Virus Infections in Patients with Hepatocellular Cancer

摘要: 目的：探讨庚型肝炎病毒感染与肝癌的关系。方法：检测128例肝细胞癌(HCC)患者和55例健康对照者血清中庚型肝炎病毒抗体(Anti-HGV)，另外采用ELISA法检测本实验检出18例Anti-HGV+血清的乙肝表面抗原(HBsAg)和丙肝抗体(Anti-HCV)。结果：Anti-HGV阳性率分别为12.5%(16/128)和36%(2/55)，两者差异显著(P<0.01)。18例Anti-HGV+血清中，HBsAg阳性率77.7%(14/18)，Anti-HGV阳性率22.2%(4/18)。表明HGV、HBV、与HCV有重叠感染现象。结论：提示广西地区HCC病毒致癌因素中，HGV感染可能是仅次于HBV及HCV的又一重要因素。

Abstract: We using ELISA respectively detected antibodies to HGV in serum samples of 128 patients with HCC and 55 controls.Antigens of the reagent were derived from HGV NS 3 and NS 5,region sequences.Besides,we using ELISA also detected HBsAg and Anti HCV in 18 serum samples of positive to Anti HGV.16 of 128(12 5%)patients and 2 of 55(3 6%)controls were positive to HGV antibodies.The difference of positive rates was significant( P0 001) .14 of 18(77 7%)was positive to HBsAg and 4 of 18(22 2%)was positive to anti HCV.In virus etiogentic of HCC in Guangxi area,HGV may probably a factor affecting subordinately to HBV and HCV.