不均等分割放射治疗口腔癌的临床研究

Reseaech on Irregular Fractionated Irradiation of Mouth Cavity Cancer

摘要: 1986年1月至1993年12月,102例口腔部进行放射治疗,其中不均等分割51例。剂量分布：6Gy（A）→1．2Gy（B）→1．2Gy（A）→1．2GY（B）→1．2GY（A）,休息二天后再重复。总肿瘤量64．8Gy/6W（10．8Gy／W×6）。同期对照组51例均等分割放疗,总肿瘤量66Gy／6．5W（10Gy／W×6．5）。结果近期疗效,不均等分割组为96．1％,均等分割组为74．5％；5年生存率不均等分割组为43．1％,均等分割组为21．6％。因此,两组有显著性差异（P＜0．05）。

Abstract: Objective From 1986 to 1993,102 mouth cavity caricinoma patients were treatecl by radiotnerapy,of them,51 were given irregular tractionated irradiation.They received 6Gy(A)→1.2Gy(B)→1.2Gy(A)→1.2GY(B)→1.2GY(A).After a rest of two days,the above cgcle was repeated.The total dose given was 64.8Gy/6W(10.8Gy/W×6).51 patients treated by conventional fractionation irradiation.The total dose given was 66Gy/6.5W(10Gy/W×6.5). Results :The improvement rate of short-term carative effect was 96.1% in the irregular tructionation irradiation graup,and 74.5% in thd conventional fraup Five-Year survival rate was 43.1% in the irregular tractionation irrodeation group,and 21.6% in the conventional one,with a remarkably difference between them(P＜0.05)