Abstract: Objective: To study the effects and toxicities of intraperitoneal combined with intravenous adminstration treatment for advanced-stage cancer in digestive system. Methods: The patients were treated with peri-chemotherapy once every week for two weeks followed by intravenous chemotherapy for two weeks. totalling six weeks as a course of treatment so as to observe the curative effect and the toxicities. Results: Amony 41 cases there were two of complete remission and 24 of partial remission with a total effective rate of 63.4 % all patients showed improved in their symptoms and signs. The toxicities mainly include scleroma at injection site pain in puncturing site. abdominal distension, lypoleucocytosis and mild digective tract reaciton. Conclosion: This treatment is effective for advanced-stage cancer without adbominal dropsy of the digestive system with mild toxicitives thus it can used as a routine treatment.