大肠癌病人血清层粘连蛋白、Ⅳ型胶原含量测定及其临床意义
Clinical Significance Of Measuring The Serum Laminin And Collagen Type Ⅳ in Patients With Colorectal Cancer
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摘要: 目的: 探讨大肠癌病人血清层粘连蛋白, Ⅳ型胶原含量与病情的关系。方法: 应用放射免疫技术测定了大肠癌患者血清层粘连蛋白(LN)及Ⅳ型胶原(Col Ⅳ)含量。结果: 大肠癌患者血清LN 、Col Ⅳ含量明显高于对照组, 相差非常显著(P <0.01); 淋巴结转移组血清LN 及Col Ⅳ含量明显高于无淋巴结转移组, 两者相差显著(P <0.05); 血清LN含量中, DukesC 期组高于DukesB期组, 两者相差显著(P<0.05); 血清ColⅣ含量由DukesB期至D期有逐渐升高趋势, 且Dukes D 期组显著高于DukesB期组, 两者相差显著(P <0.05)。结论: 提示血清LN 、Col Ⅳ含量变化与大肠癌细胞的浸润、转移等生物学行为密切相关。对判断其病情及预后可能具有一定的参考价值。Abstract: The contents of Laminin (LN) and Collagen type Ⅳ (Col Ⅳ) in serum were measured by radioimmunoassay in patients with colorectal cancer. It was showed that the content of LN and Col Ⅳ in cancer group was significantly higher than those in control group (P <0.01), the content of LN and Col Ⅳ in group with lymph node metastases was higher than those in group without lymph node metastases (P <0.05). The content of LN in Dukes C group was hight than that in Dukes B group (P <0.05). There was a tendency that the content of serum Col Ⅳ increased with the advance of the Dukes clasification and content of serum Col Ⅳ in DukesD group was higher than that in Dukes B group. This implies that the contents of the serum LN and Col Ⅳ is closely related to the tumor invasion and metastases, and the assay of the LN and Col Ⅳ in serum may be useful to the diagnosis of colorectal cancer.
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