多西紫杉醇联合氟尿嘧啶腹腔灌注治疗晚期胃癌

Docetaxel Combined with Intraperitoneal Fluorouracil Chemotherapy in Treatment of Advanced Gastric Cancer

摘要: 目的观察多西紫杉醇联合氟尿嘧啶腹腔化疗治疗晚期胃癌的临床疗效及副作用。方法多西紫杉醇75mg/m2，静滴，第1天和第8天，氟尿嘧啶1.0g，腹腔灌注，第2天，21天为一周期，共2~4周期。结果总有效率为43.24％（16/37），中位疾病进展时间为5.3月，临床受益反应评价有效者占78.38％（29/37）。主要副作用为血液毒性反应，白细胞下降发生率72.97％。结论多西紫杉醇联合氟尿嘧啶腹腔化疗治疗晚期胃癌疗效好，毒性低。

Abstract: Objective To evaluate the clinical efficacy and toxicity of docetaxel combined with intraperitoneal fluorouracil treatment in patients with advanced gastric cancer (AGC). Methods Thirty seven patients were treated with docetaxel (75mg/m2, iv, d1 and d8) and fluorouracil (1.0g,peritoneal perfusion,d2) every 3 weeks for 2~4 cycles. Results The total response rate to combination chemotherapy was 43.24% (16/37). Median time to progression (mTTP) was 5.3months. The clinical beneficial response was 78.38%(29/37).The main toxicity reaction includes hematological toxicity. The incidence of leucopenia was 72.97%. Conclusion Docetaxel combined with intraperitoneal fluorouracil in the treatment of advanced gastric cancer is effective and tolerable.