二氢乳清酸脱氢酶在恶性肿瘤进展中的作用机制研究进展

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

摘要: 二氢乳清酸脱氢酶（DHODH）是一种黄素依赖性的代谢酶，在嘧啶代谢从头合成途径中将二氢乳清酸氧化成乳清酸。同时它位于线粒体上，与细胞氧化磷酸化存在紧密联系。此外，DHODH也是铁死亡途径的一个重要抑制因子。本文主要阐述DHODH影响恶性肿瘤进展的内在作用机制，包括其在嘧啶从头合成、氧化磷酸化及铁死亡等方面的重要作用，为DHODH作为恶性肿瘤临床治疗的潜在靶点提供依据。

Abstract: Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor of the ferroptosis pathway. This study investigates the influence of DHODH on the progression of malignant tumors, including its important role in the de novo synthesis of pyrimidine, oxidative phosphorylation, and ferroptosis. The objective is to present evidence that DHODH is a potential target for the clinical treatment of tumors.