卵巢肿瘤组织谷胱甘肽S 转移酶的表达与临床及病理因素的关系

The Relationship between the Expression of Glutathione Stransf erase л in OvarianTumorand the Clinical and Patholo gical Date

摘要: 目的　检测卵巢肿瘤组织中谷胱甘肽S转移酶 (GST л)的表达, 探讨其与临床及病理的关系。方法　采用免疫组化SP法检测 77例卵巢恶性肿瘤, 30例卵巢良性肿瘤中GST π的表达。结果 (1)卵巢恶性肿瘤术前接受化疗组GST π阳性表达率 5 2 .38%, 未接受化疗组 32 .14%, 卵巢良性肿瘤组 6 .6 7%, 三组比较有显著性差异 (P <0 .0 1)。 (2 )低分化肿瘤较高、中分化者GST л阳性表达率显著增高 (P <0 .0 1)。结论　卵巢恶性肿瘤组织中GST л表达与其化疗有关, 对临床判断化疗敏感性和预后有一定参考价值。

Abstract: Objective To study the relationship between the expression of glutathione stransferase л(GST л)in ovarian cancer tissue and the clinical and pathological result. Methods The expression of GST л in 77 cases of ovarian cancer, 30 ovarian benign tumors was determined by using immunohistochemical SP method. Results (1)Positive expression with GST л was 52.38% in malignant tumors having chemotherapy before operations, 32.14% in having no chemotherapy and 6.67% in benign ovarian tumors( P<0.01 ).(2)The exp...