抗癌灵治疗原发性肝癌的实验研究

Experimental stady on kangailing decoction in the treatment of primary carcinoma of liver

摘要: 目的　观察抗癌灵水煎剂对小鼠移植性肝癌 (H2 2 )的治疗作用。方法　以瘤株 (H2 2 )接种小鼠创作模型, 设正常对照组、荷瘤模型组及抗癌灵治疗组, 共 3组, 观察各组小鼠瘤重和抑瘤率、肿瘤坏死因子(TNF)的体内活性表达、各组H2 2 小鼠生命延长率以及对肝癌细胞增殖周期的影响等指标。结果　用抗癌灵治疗后的H2 2 小鼠其抑瘤率达 61 .2 0 %, 明显高于模型组 (P <0 .0 1 ), 并能抑制荷瘤肌体TNF水平的异常表达, 提高H2 2 荷瘤小鼠的生命延长率, 而且该药还能阻滞肿瘤细胞周期G1期向S期进展, 从而阻断DNA的合成和复制。结论　抗癌灵对小鼠肝癌 (H2 2 )具有明显的杀伤作用

Abstract: Objective To investigate the Kangailing Decoction in the treatment of transplanted hepatocarinoma(H 22 ) of Mice. Methods To use H 22- inoculated mice in pattern. For normal control, H 22 pattern and the treatment of Kangailing Decoction group.It should respectively be observated that neoplasia weight, the rate of neoplasia inhibition, the Tumor Necrosis Factor(TNF) activity expression, the rate of elongation for life, and the influence of the proliferation periodic of liver carcinoma cells for...