环氧合酶-2对胃癌血管内皮生长因子及血管形成的影响

The effects of COX-2 expression on vascular endothelial growth factor and angiogenesis in gastric carcinoma

摘要: 目的　探讨环氧合酶 2 (COX 2 )对胃癌血管内皮生长因子 (VEGF)的表达及血管生成的影响。方法　应用免疫组织化学技术检测胃癌组织中COX 2, VEGF表达和微血管密度 (MVD)。结果　COX 2在62 .2 %胃癌组织中表达增高, COX 2表达与VEGF表达显著相关 (γS=0 .5 85, P <0 .0 1 ), 且COX 2和VEGF均阳性的胃癌组织MVD(64.0± 2 5 .4)亦明显高于两者均阴性者 (3 0 .7± 1 1 .5 ) (P <0 .0 1 )。结论　胃癌组织中存在COX 2的高表达, COX 2通过增加VEGF表达而促进肿瘤血管形成

Abstract: Objective To investigate the effects of COX-2 expression on vascular endothelial growth factor (VEGF) and angiogenesis in gastric carcinoma. Methods The expression of COX-2, VEGF and microvascular density (MVD) was examined by immunohistochemical staining. Results COX-2 expression was detected in 62.2% of gastric carcinoma;The expression of COX-2 was significantly correlated with VEGF ( P <0.01);Increased expression of COX-2 and VEGF was significantly correlated with an increase in MVD ( P <...