造血干细胞移植治疗恶性血液病疗效分析

The Effect s Analysis of Hematopoietic Stem Cell Transplantation(HSCT) for Hematological Malignancies

摘要: 目的　比较自体与异体造血干细胞移植 (HSCT)治疗白血病和非霍杰金氏淋巴瘤 (NHL)的疗效和移植相关死亡。方法　 2 2 2例白血病和NHL中, 112例接受自体HSCT、110例接受异体HSCT, 其中38例急性早幼粒细胞白血病 (M3 )和 36例NHL均为自体HSCT。移植预处理方案包括 :14 9例TBI +Cy、2 3例改良Bucy、5 0例MACC方案。结果　全部患者均获得造血重建, 在自体与异体移植后白细胞>1.0× 10 9/L和血小板 >2 0× 10 9/L的时间, 二组分别为 (14 .3± 6 .1)d和 (17.8± 9.2 )d与 (15 .1±4 .6 )d和 (19.6± 10 .3)d, 二组比较造血重建时间无差异 (P >0 .0 1)。非M3 白血病自体与异体移植后 5年估计无病生存率为 (5 2 .0± 5 .8) %和 (6 2 .4± 6 .2 ) %、复发率为 (44 .7%和 14 .5 % ), M3 白血病自体移植无病生存率 (93.6± 4 .4 ) %、复发率 5 .3%, NHL自体移植无病生存率 (6 6 .3± 8.0 ) %、复发率 2 2...

Abstract: Objective To investigate the effects and Transplant related mortality(TRM) of autologous (auto ) and allogeneic(allo ) hematopoietic stem cell transplantation(HSCT) for leukemia and Non Hodgkin s lymphoma (NHL). Methods 222 patients with leukemia and NHL, 112 patients were treated with auto HSCT and 110 with allo HSCT. All patients of 38 acute promyelocytic leukemia (APL) and 36 patients NHL were treated with auto HSCT.149 cases were received TBI (total body irradiation)+CY (CTX), 23 cases modifie...