纯化的自体CD34~+细胞移植治疗恶性血液病临床对照观察
A Clinical Comparison of CD34~+ Selected Autologous Peripheral Blood Stem Cells Transplantation in Malignant Hematologic Disease
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摘要: 目的 分析CD34+ 纯化自体造血干细胞移植治疗恶性血液病的临床疗效。方法 11例病人进行了CD34+ 纯化自体造血干细胞移植, 8例患者进行了未分选的自体造血干细胞移植, 动员方案为CTX+Vp 16联合G CSF。CD34+ 细胞分选采用CliniMACS系统。结果 分选后CD34+ 细胞纯度达到(88.99± 6 .88) %, 回收率达到 (6 9.0 6± 17.0 7) %。 11例分选患者感染率为 (5 / 11例 ), 复发率为 (1/ 11例 ), 死亡率为 (3/ 11例 )。外周血中性粒细胞 >0 .5× 10 9/L时间为 (11± 1)天, 血小板 >2 0× 10 9/L为(13± 3)天, 8例未行CD34+ 分选患者的感染率 (4/ 8例 ), 复发率为 (3/ 8例 ), 死亡率为 (5 / 8例 )。外周血中性粒细胞 >0 .5× 10 9/L时间 (11± 1)天和血小板 >2 0× 10 9/L(14± 4 )天。结论 利用CliniMACs系统体外进行外周血CD34+ 细胞的富集与纯化纯度、回收率均满意, 自体移植后造血功能重建顺利 ;与对照相比造血重建时间、感染率...Abstract: Objective To compare the clinical result of CD34 + selected autologous peripheral blood stem cells transplantation(APBSCT)in malignant hematologic disease. Methods 11 patients received CD34 + selected APBSCT, 8 patients received unselected APBSCT.Peripheral blood stem cells from patients were mobilized by CTX +VP 16 and G CSF, and purified by CliniMACS device. Results PBSC after selected, it gave a median recovery of (69.06 ± 17.07)% and median purity of (88.99 ± 6.88)%, of 11 CD34 + s...
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