鼻咽癌放射治疗后诱发第二肿瘤临床分析

18 cases of radiation induced malignant tumor in nasopharyngeal carcinoma

摘要: 目的　探讨放射治疗诱发恶性肿瘤的发生率、潜伏期、治疗及预后。方法　回顾性分析 18例鼻咽癌放射治疗后诱发的恶性肿瘤, 男 12例, 女 6例。原发肿瘤均为低分化鳞癌, 治疗的放射源为6 0 Co或8MV X射线, 常规分割照射, 照射剂量为 70～ 86Gy。结果　 18例在放射治疗后 3～ 19年在原照射部位出现了恶性肿瘤, 其中牙龈鳞癌 5例, 外耳道鳞癌 3例, 硬腭鳞癌 2例, 舌鳞癌 2例, 皮肤癌 2例, 鼻咽部肉瘤 2例, 鼻咽恶性纤维组织细胞瘤 1例, 上颌窦骨肉瘤 1例。结论　放射治疗诱发恶性肿瘤与照射剂量有关, 其潜伏期较长, 适当的治疗方法可提高患者的生存率和改善患者的生存质量。

Abstract: Objective To study the incidence, latency, treatment and Prognosis of radiation induced malignant tumors. Methods A retrospective study was done on 18 cases of radiation induced malignancies. All original cancers were nasopharyngeal carcinoma, 12males and 6 femaes. The initial radiotherpy was 60 Co or 8MVX ray, Conventionally fractionated at dose of 70 86GY. Results After 3～19 years of the initial radiotherapy, 18 Patients developed tumors within the portal. There were: 5 squamous carcinoma of gum,...