Abstract: Objective 　To investigate the roles of cyclin-dependent-kinase 2 (cdk2) and cyclin E in pathogenesis of renal cell cancer and their relationships with tumor biological behavior. Methods 　Immunohis-tochemical methods were adopted to examine expressions of cdk2, cyclin E and PCNA in 48 cases with renal cell cancer and 12 cases with normal kidney tissue. Results 　Expressions of both cdk2 and cyclin E in renal cell cancer were significantly higher than that in normal kidney tissues. Expressions of cdk2 and cyclin E in renal cell cancer were significantly related with PCNA index. While their expressions were not closely associated with tumor grade, stage, lymph node metastasis and pathological types. High-coex-pression of cdk2 and cyclin E was found in 47. 1 % of renal cell cancer, which was closely related with tumor grade, stage and lymph node metastasis. Conclusion 　Abnormal expressions of cdk2 and cyclin E play important roles in pathogenesis of renal cell cancer. Co-examining cdk2 and cyclin E expression may be valuable for predicting biological behavior of renal cell cancer.