Abstract: Objective 　To investigate the correlation of XPC int ron 9 PAT +/-and exon 15 A2920C SNPs with susceptibility to esophageal squamous cell carcinoma ( ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region of Hebei Province. Methods 　XPC intron 9 PAT +/- and exon 15 A2920C SNPs were genotyped by polymerase chain reaction-rest riction fragment length polymorphism ( PCR-RFL P) analysis in 327 ESCC patient s, 253 GCA patient s and 612 healthy controls. Results 　The overall genotype and allelotype distributions of XPC intron 9 PAT +/- and exon 15 A2920C in ESCC and GCA patients were not significantly different from that in healthy controls ( P > 0. 05 ) . When stratified for smoking status and UGIC family history, compared with A/ A genotype, C/ C genotype significantly increased the risk of developing ESCC in non2smoker group age and gender and UGIC family history adjusted odds ratio (OR) = 2. 09, 95 %CI = 1. 14～3. 81 . Conclusion 　C/ C genotype of XPC exon 15 may be one of the factors that affect the risk of developing ESCC in non-smoking population in the high incidence region of Hebei Province.