沙立度胺抑制乳腺癌细胞增殖的作用机制

doi:10.3971/j.issn.1000-8578.657

沙立度胺抑制乳腺癌细胞增殖的作用机制[J]. 肿瘤防治研究, 2008, 35(08): 560-562. DOI: 10.3971/j.issn.1000-8578.657

引用本文:

沙立度胺抑制乳腺癌细胞增殖的作用机制[J]. 肿瘤防治研究, 2008, 35(08): 560-562. DOI: 10.3971/j.issn.1000-8578.657

Antiproliferation Effect and Its Mechanism of Thalidomide on Breast Cancer Cells in vitro[J]. Cancer Research on Prevention and Treatment, 2008, 35(08): 560-562. DOI: 10.3971/j.issn.1000-8578.657

Citation:

Antiproliferation Effect and Its Mechanism of Thalidomide on Breast Cancer Cells in vitro[J]. Cancer Research on Prevention and Treatment, 2008, 35(08): 560-562. DOI: 10.3971/j.issn.1000-8578.657

沙立度胺抑制乳腺癌细胞增殖的作用机制

Antiproliferation Effect and Its Mechanism of Thalidomide on Breast Cancer Cells in vitro

摘要

摘要: 目的研究沙立度胺抑制乳腺癌细胞增殖的机制。方法流式细胞仪检测沙立度胺对细胞凋亡和细胞周期的影响;半定量RT-PCR方法观察沙立度胺对MCF-7和MDA-MB-231细胞VEGF mR-NA表达的影响。结果沙立度胺作用后的乳腺癌细胞在流式细胞分析的DNA直方图上显现细胞凋亡峰(亚G1期);沙立度胺抑制两株细胞VEGF mRNA的表达。结论沙立度胺可能通过诱导MCF-7和MDA-MB-231细胞凋亡以及抑制细胞VEGF mRNA表达从而抑制MCF-7和MDA-MB-231细胞增殖。

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