CD105 、COX-2 和VEGF 在结直肠癌中的表达及其与血管新生的关系

doi:10.3971/j.issn.1000-8578.585

CD105 、COX-2 和VEGF 在结直肠癌中的表达及其与血管新生的关系

Expression of CD105, COX-2 and VEGF and Their Relationship with Angiogenesis in Colorectal Carcinoma

摘要

摘要: 目的探讨结直肠癌中CD105在新生血管中的表达，环氧化酶（COX-2）和血管内皮生长因子（VEGF）表达及其与血管生成的关系。方法应用免疫组化SP法检测58例结直肠癌CD105表达的微血管密度，以及COX-2、VEGF的表达。结果 58例结直肠癌中，CD105表达的MVD值为（36．50±9．59），COX-2和VEGF的阳性表达率各为69％和67．2％。COX-2或VEGF表达阳性组的MVD值显著高于COX-2或VEGF表达阴性组（P〈0．05）。COX-2和VEGF均阳性组的MVD值显著高于均阴性组（P〈0．01）。COX-2与VEGF表达显著正相关；COX-2、VEGF表达均与MVD显著正相关（P〈0．01）。结论 CD105是结直肠癌新生血管的特异性标记物，COX-2表达与结直肠癌血管生成有关，VEGF可能是COX-2诱导血管生成的重要介质。

Abstract: Objective 　To investigate the expression CD105 in newborn vessel of COX-2 and VEGF in colorectal carcinoma and their relationship with angiogenesis. Methods 　Immunohisto-chemical staining (S-P method) for CD105, COX-2 and VEGF was performed in 58 cases of colorectal carcinoma ; the microvessel density (MVD) was marked by CD105. Results 　The value of MVD with marked CD105 was (36. 50 ±9. 59), the positive rate of COX-2 and VEGF were respectively 69 % and 67. 2 %. The MVD in COX-2 positive group or VEGF positive group was significantly higher than that in COX-2 negative group or VEGF negative group ( P < 0. 01) . The MVD in the group of both COX-2 and VEGF positive was significantly higher than that in both negative groups. There was a significant positive correlation between the expression of COX-2 and VEGF. Conclusion 　CD105 was a specific marker of newborn vessel in colorectal carcinoma ; COX-2 was correlated to angiogenesis and VEGF may be an important mediator in this process.

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