C-erbB-2 及nm23 在乳腺癌中的表达及其临床意义

Expression of C-erbB-2 andnm 23 Proteinin Breast Carcinoma and Their Clinical Significance

摘要: 目的　研究C erbB 2和nm2 3在乳腺癌中的表达及临床预后价值。方法　应用免疫组化S P法检测 6 5例临床随访资料完整的乳腺癌患者标本中, C erbB 2和nm2 3的表达情况, 用Cox回归分析其预后意义。结果　C erbB 2及nm2 3阳性表达率分别为 4 0 %和 5 5 .4 %。C erbB 2表达与腋淋巴结状态呈正相关, 与生存率呈负相关, 而nm2 3表达则相反。多因素Cox回归分析显示, 腋淋巴结状态, C erbB 2及nm2 3过度表达等 3项指标反映乳腺癌预后情况, 危险度分别为3.10 4 6, 2 .6 5 82, 0 .370 4。结论　C erbB 2及nm2 3是仅次于乳腺癌腋淋巴结状态的独立的预后指标, 联合检测可提高其预后价值。

Abstract: Objective To study the expression and clinical significance of C-erbB-2 and nm23 protein in breast carcinoma. Methods Tissue samples from 65 cases of breast carcinoma with full follow-up data were examined by immunohistochemical S-P methods and overexpression of their C-erbB-2 and nm23 protein was evaluated. Their prognostic value was analyzed by cox regression mode. Results Of the 65 breast carcinoma specimens, 40% were C-erbB-2 positive and 55.4% were nm23 positive. Overexpression of C-erbB-2 was ...